Evaluation of the sleep modulating effects of methanolic extracts of Strychnos spinosa and Strychnos innocua fruits in mice

This study aimed to evaluate the sleep modulating properties of Strychnos spinosa and innocua fruits in Swiss albino mice. The depressant effect extracts on central nervous system was studied using a diazepam-induced model mice were divided into four groups six each. test received at doses 250, 500, 1000 mg/kg body weight intraperitoneally. In contrast, control group distilled water 10 ml/kg. Diazepam (Ranbaxy®, India) used as standard drug administered 30 minutes after initial treatment. lethal (LD50) two estimated be >5000 mg/kg. results obtained from onset rats methanol spinosa, showed that mg/kg, respectively, did not significantly (p >0.05) alter when compared with control. treated fruit indicated dose-dependent decrease pattern. also revealed prolonged duration all experimental group. 500 <0.05) manner extract significant conclusion, high LD50 observed this suggests are relatively safe contain promising bioactive ingredients cause modulation